| The application of bio systems in the development of | | | | algorithms are available to researchers interested in |
| gene tools has proven efficacy for altered | | | | determining the aging process from the approach of |
| methylation patterns that develop genetic disorders, | | | | DNA for mapping chromatin domains, while reducing |
| cancer and aging. Primer design studies has shown | | | | costs.Research lead by the National Institute of Aging |
| changes occurring in DNA used as molecular markers | | | | (NIA) found that defective WRNp protein is involved |
| of cell degradation mechanisms leading to disease or | | | | in premature aging disorder, helping scientist to |
| changes in tissue structure and function.Real time | | | | understand primer design analysis toward DNA repair, |
| PCR is a reliable and easy to use technique to detect | | | | which becomes less efficient during normal human |
| and measure DNA methylation by direct monitoring | | | | aging. The NIA is one of the 25 institutes of the |
| of a PCR reaction useful for both research and | | | | National Institutes of Health, leading the Federal |
| routine diagnostics. Because aging is the result of | | | | effort in supporting research on aging.Gene Tools, |
| general deterioration of the body's cells increasing | | | | including Real time PCR, are powerful identifiers of |
| with age, primer design analysis can help to determine | | | | gene expression patterns modifying DNA that |
| contributing factors to delay the process.New gene | | | | eventually contribute to develop aging-related |
| tools are the response to genomics-based approach | | | | diseases such as Parkinson disease, Alzheimer's |
| to human genetics proposed in the 1990's, however, | | | | disease and the Hutchinson-Gilford progeria syndrome |
| aging treatments based on the study and capture of | | | | (HGPS) referred to as a premature aging |
| the human DNA sequence variations information are | | | | syndrome.Copyright @2006, 4th Media |
| not financially feasible yet. However, by lowering the | | | | CorporationYou have permission to publish this article |
| costs of real time PCR will increase the power of | | | | electronically free of charge, as long as the bylines |
| gene tools to identify the origin of cells aging.Stacey | | | | and links in the body of the article and the bylines are |
| Gabriel, director of the Broad Institute's Genetic | | | | included.Natalie Aranda writes about health, skin care |
| Analysis said, "when we started doing this work a | | | | and fitness. The application of bio systems in the |
| number of years ago, determining the genotype of a | | | | development of gene tools has proven efficacy for |
| SNP in a patient cost nearly a dollar, and we could do | | | | altered methylation patterns that develop genetic |
| hundreds a day. Today the prices have dropped in | | | | disorders, cancer and aging. Primer design studies has |
| many cases to a fraction of a penny per genotype, | | | | shown changes occurring in DNA used as molecular |
| and we can do millions a day. This is the difference | | | | markers of cell degradation mechanisms leading to |
| between not being able to do the studies, and | | | | disease or changes in tissue structure and function. |
| getting them done rapidly and well."Primer design is | | | | Real time PCR is a reliable and easy to use technique |
| the initial element required to set an anti-aging | | | | to detect and measure DNA methylation by direct |
| methodology based on gene structure, hence allowing | | | | monitoring of a PCR reaction useful for both research |
| improved automation of real time PCR. In addition, a | | | | and routine diagnostics. |
| large number of computer-based primer design | | | | |