| The application of bio systems in the | | | | primer design algorithms are available to |
| development of gene tools has proven efficacy | | | | researchers interested in determining the |
| for altered methylation patterns that develop | | | | aging process from the approach of DNA for |
| genetic disorders, cancer and aging. Primer | | | | mapping chromatin domains, while reducing |
| design studies has shown changes occurring in | | | | costs.Research lead by the National Institute |
| DNA used as molecular markers of cell | | | | of Aging (NIA) found that defective WRNp |
| degradation mechanisms leading to disease or | | | | protein is involved in premature aging |
| changes in tissue structure and function.Real | | | | disorder, helping scientist to understand |
| time PCR is a reliable and easy to use | | | | primer design analysis toward DNA repair, |
| technique to detect and measure DNA | | | | which becomes less efficient during normal |
| methylation by direct monitoring of a PCR | | | | human aging. The NIA is one of the 25 |
| reaction useful for both research and routine | | | | institutes of the National Institutes of |
| diagnostics. Because aging is the result of | | | | Health, leading the Federal effort in |
| general deterioration of the body's cells | | | | supporting research on aging.Gene Tools, |
| increasing with age, primer design analysis | | | | including Real time PCR, are powerful |
| can help to determine contributing factors to | | | | identifiers of gene expression patterns |
| delay the process.New gene tools are the | | | | modifying DNA that eventually contribute to |
| response to genomics-based approach to human | | | | develop aging-related diseases such as |
| genetics proposed in the 1990's, however, | | | | Parkinson disease, Alzheimer's disease and |
| aging treatments based on the study and | | | | the Hutchinson-Gilford progeria syndrome |
| capture of the human DNA sequence variations | | | | (HGPS) referred to as a premature aging |
| information are not financially feasible yet. | | | | syndrome.Copyright @2006, 4th Media |
| However, by lowering the costs of real time | | | | CorporationYou have permission to publish |
| PCR will increase the power of gene tools to | | | | this article electronically free of charge, |
| identify the origin of cells aging.Stacey | | | | as long as the bylines and links in the body |
| Gabriel, director of the Broad Institute's | | | | of the article and the bylines are |
| Genetic Analysis said, "when we started doing | | | | included.Natalie Aranda writes about health, |
| this work a number of years ago, determining | | | | skin care and fitness. The application of bio |
| the genotype of a SNP in a patient cost | | | | systems in the development of gene tools has |
| nearly a dollar, and we could do hundreds a | | | | proven efficacy for altered methylation |
| day. Today the prices have dropped in many | | | | patterns that develop genetic disorders, |
| cases to a fraction of a penny per genotype, | | | | cancer and aging. Primer design studies has |
| and we can do millions a day. This is the | | | | shown changes occurring in DNA used as |
| difference between not being able to do the | | | | molecular markers of cell degradation |
| studies, and getting them done rapidly and | | | | mechanisms leading to disease or changes in |
| well."Primer design is the initial element | | | | tissue structure and function. Real time PCR |
| required to set an anti-aging methodology | | | | is a reliable and easy to use technique to |
| based on gene structure, hence allowing | | | | detect and measure DNA methylation by direct |
| improved automation of real time PCR. In | | | | monitoring of a PCR reaction useful for both |
| addition, a large number of computer-based | | | | research and routine diagnostics. |