| Isonicotinic acid hydrazide, commonly called isoniazid | | | | metabolism of phenytoin. Pyridoxine is the drug of |
| (INH), is an antimicrobial agent that was used to treat | | | | choice for INH-induced seizure or coma. If pyridoxine |
| tuberculosis (TB). The toxic response of the body to | | | | is not available, lorazepam or phenobarbital may be |
| the substance, perhaps by allergic reaction or | | | | administered on a temporary basis, measures to |
| overdose. Inuits and American Indians are at | | | | control the seizure in expectation of pyridoxine |
| increased risk of tuberculosis and, subsequently, INH | | | | administration. Vitamins are organic substances |
| toxicity. Acute toxicity can occur in all age groups. | | | | required by the body in small amounts for various |
| Contributing factors of isoniazid toxicity HIV / AIDS | | | | metabolic processes. |
| epidemic, alcoholism and homelessness. The | | | | Isoniazid Toxicity Treatment and Prevention Tips |
| symptoms of toxicity include isoniazid, slurred speech, | | | | 1. Vitamins are organic substances required. |
| mtabolic acidosis, weakness, dizziness, nausea, | | | | 2. Barbiturates is also recommended. |
| vomiting, hallucinations, hyperglycemia and respiratory | | | | 3. Supportive therpy includes airway, breathing and |
| distress. | | | | circulation are useful. |
| The treatment is mostly supportive, which includes | | | | 4. Benzodiazepines can be used to potentiate the |
| airway, breathing and circulation. Sevral | | | | anticonvulsant effect of pyridoxine. |
| benzodiazepines and barbiturates can be used to | | | | 5. Lorazepam (Ativan) ncreasing the action of GABA, |
| potentiate the effect of pyridoxine anticonvulsant. | | | | which is a major inhibitory neurotransmitter in the |
| Use with caution because phenytoin INH inhibits | | | | brain. |