| -link"> | | | | study by Moongkarndi and others (J Ethnopharmacol |
| Mangosteen Juice's secret potent ingredient are | | | | 2004; 90(1):161-166) on the effect of mangosteen |
| Xanthones... Learn about Mangosteen Xanthones here. | | | | pericarp extract on human breast cancer cells found |
| Scientific research into the health benefits of | | | | that it had "potential for cancer chemoprevention.The |
| xanthones from mangosteen has been conducted | | | | antioxidative ability of the xanthone mangostin was |
| since the 1970s and, although there is still much more | | | | shown by Williams and others (Free Radic Res 1995; |
| work to be done, the results thus far are very | | | | 23(2):175-184) to lower "bad" cholesterol levels. This |
| promising. Mangosteen is a complex research subject | | | | helps prevent the buildup of plaque within blood |
| because it contains over 40 xanthones. Choices, | | | | vessels and lowers the risk of heart disease.Several |
| therefore, need to be made regarding which | | | | research studies have verified the traditional use of |
| particular xanthone should be the focus of any given | | | | mangosteen as an antibacterial agent. For example, a |
| study. Two of the most studied xanthones are | | | | study by Iinuma and others, published in the Journal |
| alpha-mangostin and gamma-mangostin.Both of these | | | | of Pharmacy and Pharmacology in 1996, showed that |
| compounds have been shown to be very effective | | | | alpha-mangostin exhibited strong antibacterial activity |
| anti-inflammatory agents. Several studies led by | | | | against Staphylococcus aureus. The authors |
| Nakatani, published in Biochemical Pharmacology in | | | | concluded that "the compounds might find wide |
| 2002 and Molecular Pharmacology in 2004, confirmed | | | | pharmaceutical use." Another study involving |
| that gamma-mangostin is a potent COX-2 inhibitor. | | | | alpha-mangostin showed that it was effective against |
| This means that it is a factor in reducing inflammation | | | | Mycobacterium tuberculosis.Gamma-mangostin has |
| and its associated pain. The authors conclude that | | | | also been shown to be effective against some |
| gamma-mangostin "is a new useful lead compound | | | | viruses. One study (Planta Med 1996; 62(4):381-382) |
| for anti-inflammatory drug development."Several | | | | showed that it was able to cause the HIV-1 virus to |
| xanthones have been studied for their efficacy in | | | | remain immature and incapable of infection.It should |
| treating cancer. A paper published in the Journal of | | | | be noted that all the above research results were |
| Natural Products in 2003 showed that a variety of | | | | obtained in laboratory studies. To be more |
| xanthones from mangosteen were all able to inhibit | | | | meaningful, follow up clinical trials using human |
| the growth of human leukemia cells. The same | | | | subjects need to be carried out. However, the results |
| authors in a follow up study (Bioorg Med Chem. 2004 | | | | to date indicate that xanthones from mangosteen |
| Nov 15;12(22):5799-806) concluded that | | | | may have a major role to play in the treatment of a |
| alpha-mangostin would be a candidate for preventive | | | | wide range of health problems. |
| and therapeutic application for cancer treatment. A | | | | |