| Although antibiotics had been discovered a few years | | | | 1. The antibacterial activity best resulted in |
| before, sulfonamide and penicillin proved no effect on | | | | Streptomycin, Isoniazid and Rifampicin. |
| the bacteria causing Tuberculosis. After years of | | | | 2. The inhibition of the development of resistance |
| research In California about soil fungus, in 1039 | | | | with best results in Rifampicin, Ethambutol and |
| Waksman isolated the fungus Actynomices that was | | | | Izoniazid. |
| able to inhibit the development of Mycobacterium | | | | After a month of treatment with the four basic |
| Tuberculosis. But the chemo was to dangerous toxic | | | | antibiotics, the patient should be fever free, feel |
| and could not be used in treating Tuberculosis. | | | | much improved and show decreased number of |
| In 1943streptomycin was found inside Streptomyces | | | | bacteria in the sputum. The weight of the patient |
| griseus and it was proven to totally inhibit the | | | | must increase and the lesions visible on the X-rays |
| bacterial strains. In 1944 it was administered to a | | | | should minimize. As the medication persists the |
| Tuberculosis patient that immediately improved. | | | | bacterial organism in the sputum will become more |
| Although streptomycin causes side effects like | | | | and more difficult to be cultivated on synthetic |
| damages to the inner ear, it was for a few years the | | | | cultures inside the laboratories. |
| best medication against Mycobacterium. | | | | If no signs of improvement appear on the |
| The medical treatment of Tuberculosis was put in | | | | radiography after 3 months, the medication and the |
| danger after the assumption that bacteria rapidly | | | | patient's compliance must be again verified. Most |
| gains resistance even to the newer discovered | | | | relapses after treatment appear in the first 6 months |
| antibiotics. But the issue was quickly solved by using | | | | after the patient has stopped taking chemo. Also the |
| combinations of antibiotics in the treatment. | | | | capacity of developing resistance must be taken into |
| After streptomycin other major anti Tuberculosis | | | | consideration. The National Tuberculosis Center must |
| chemo were introduced. P-aminosalicilic acid, Isoniazid, | | | | carefully monitories rebel cases of Tuberculosis. |
| Pyrazinamide, Ethambutol, Rifampicin and Cycloserin | | | | In case of a reoccurrence at the same patient, |
| showed benefic results in the cure of Tuberculosis. | | | | doctors must find another schedule of therapy as |
| Newer Aminiglicosides such as Viomycin and | | | | the bacteria has already developed resistance to the |
| Kanamycin as well as the quinolones Ciprofloxacin and | | | | antibiotics used before. A possibility is adding other |
| Ofloxacin are only prescribed in cases of resistant | | | | few antibiotics to the initial medication. If bacteria is |
| strains. Latest treatment methods like the Macrolides | | | | resistant to all kind of standard chemical products, |
| or the combination of Beta-lactamase and | | | | other drugs, more toxic however will be put in the |
| Beta-lactams have not been yet enough studied. | | | | schedule: Ethionamide, Cycloserine, Viomycin, |
| The two most important characteristics of the | | | | Kanamycin, Pyrazinamide or Capreomycin. |
| antituberculous ant biotherapy are: | | | | |